Welcome to Soo Lee Lab at OHSU

"Genius is one per cent inspiration and ninety-nine per cent perspiration. Accordingly, a 'genius' is often merely a talented person who has done all of his or her homework"  Thomas Edison

 
 

The CNS consists of myriads of cell-types with diverse morphology and functionality. These anatomical, cellular and molecular complexities present a challenge for mechanistic studies of CNS development. One of the most fundamental questions in neuroscience is how an amazing number of neural cell-types are produced at specific time and space, acquire their specialized connections and functions, and form neural circuits.

Our long-term research goal is to understand processes governing generation of diverse neural cell-types and formation of neural circuits and how disruption of these processes lead to various CNS developmental disorders. Our lab has been unraveling the important molecular and cellular mechanisms to generate cellular diversity in developing CNS. Using integrated experimental tools, we have made pivotal contributions to the understanding of gene regulatory networks underlying cell-fate specification and maturation in the developing spinal cord and forebrain. 

The FoxG1 gene encodes a transcription factor that plays critical roles in forebrain development. Mutations or duplication of this gene result in ‘FoxG1 syndrome’, also known as ‘congenital Rett-like syndrome’. We have recently initiated a major effort to understand the molecular basis of this syndrome in a hope to find treatment for this devastating neurodevelopmental disorder.

Gene Networks in CNS Development and Disorders