In 2003, we published a landmark paper describing purification of the first mammalian histone H3-lysine 4-methyltransferase (H3K4MT) complexes that contain either the H3K4MT MLL3 or its paralog MLL4 (Mol Cell Biol 23:140, 2003; PNAS 103:15392, 2006). We have been a pioneer in dissecting the physiological roles of these MLL3- and MLL4-complexes ever since. Our current focus is on roles of these complexes in diverse metabolic processes as well as in a newly emerging theme for intriguing interplay between diet and tumorigenesis.

 

Welcome to Jae Lee’s Lab

at OHSU, Portland, Oregon


Gene Regulation in Metabolism